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Stereoselective pharmacokinetics of oxprenolol, propranolol, and verapamil: Species differences and influence of endotoxin

✍ Scribed by Martine E. Laethem; Frans M. Belpaire; Pascal Wijnant; Marc G. Bogaert

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
625 KB
Volume
7
Category
Article
ISSN
0899-0042

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✦ Synopsis

The influence of endotoxin-induced inflammation was studied on the pharmacokinetics of the enantiomers of the racemic drugs oxprenolol, propranolol, and verapamil in rabbits and dogs. Enantioselective pharmacokinetics were seen for oxprenolol and propranolol in the rabbit and for propranolol and verapamil in the dog. In the dog, the enantioselective differences in plasma concentrations are due to differences in both protein binding and metabolism, whereas in the rabbit the ddferences are due solely to ddferences in metabolism. In both species endotoxin treatment increases the plasma concentrations of the enantiomers of the three drugs; both protein binding and metabolism are influenced. In rabbits and in dogs, the influence of endotoxin on the disposition of the three drugs is less enantioselective than was previously observed in the rat.

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