Papain-catalyzed synthesis of peptide is
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M. Schuster; B. Munoz; W. Yuan; C.-H. Wong
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Article
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1993
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Elsevier Science
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French
โ 256 KB
The thiol protease papain catalyses the transfer of the Cbz-Gly moiety from the donor substrate Cbz-Gly-OMe to the amino group of various a-hydroxyand a-keto-amines, providing a new route to peptide isosteres. Isosteres of natural peptides, especially of dipeptides, are valuable building blocks for