๐”– Bobbio Scriptorium
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Papain-catalyzed synthesis of peptide isosteres

โœ Scribed by M. Schuster; B. Munoz; W. Yuan; C.-H. Wong

Book ID
104224833
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
256 KB
Volume
34
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The thiol protease papain catalyses the transfer of the Cbz-Gly moiety from the donor substrate Cbz-Gly-OMe to the amino group of various a-hydroxyand a-keto-amines, providing a new route to peptide isosteres.

Isosteres of natural peptides, especially of dipeptides, are valuable building blocks for the synthesis of mechanism-based protease inhibitors1 and proteolytically stable peptides. As more and more peptide

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Papain catalyzed synthesis of glyceryl esters of N-protected amino acids and peptides for the use in trypsin catalyzed peptide synthesis
โœ Yuri V. Mitin; Karin Braun; Peter Kuhl ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 113 KB ๐Ÿ‘ 2 views

Papain catalyzed synthesis of glyceryl esters of BOC(Z)-protected amino acids and peptides was performed at 40-50ยฐC in a 50 molar excess of glycerol. Equilibrium was achieved in 6-7 h. The maximal yield of esters (50-70%) was obtained at 10% of water and pH 3.2-3.4. A lower water concentration resul