Stereoselective inhibition of human, mouse, and horse cholinesterases by bambuterol enantiomers
✍ Scribed by Anita Bosak; Ivana Gazić; Vladimir Vinković; Zrinka Kovarik
- Book ID
- 113517709
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 236 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0009-2797
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The effect of galanthamine (GAL) and its 2 major metabolites on human cholinesterases has been explored. Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significant
## Abstract Methamidophos (O, S‐dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied __in vitro.__ The pseudo‐biomolecular rate constant of inhibition was 3.14 ± 0.22 × 10^3^ M^−1^ min^−1^ for erythrocyte cholinesterase and 1.85 ± 0.01 × 10^3^ M^−1^ m