Stereoselective effects of methylphenidate on motor hyperactivity in juvenile rats induced by neonatal 6-hydroxydopamine lesioning
β Scribed by Eugen Davids; Kehong Zhang; Frank I. Tarazi; Ross J. Baldessarini
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 130 KB
- Volume
- 160
- Category
- Article
- ISSN
- 0033-3158
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The relative roles of norepinephrine (NE) and dopamine (DA) in sustaining neonatal hyperactivity were assessed in rats given 6-hydroxydopamine (6-OHDA) neonatally into the lateral ventricles after pargyline (P) or desmethylimipramine (DMI) pretreatment. On day 5 after birth, male and female rat pup
In rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, striatal D,-receptor-stimulated c-fos expression and turning behavior are positively modulated by D, receptor stimulation and by blockade of N-methyl-D-aspartate (NMDA) or muscarinic receptors. Combined D1