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Effects of dopamine D4receptor-selective antagonists on motor hyperactivity in rats with neonatal 6-hydroxydopamine lesions

โœ Scribed by Kehong Zhang; Eugen Davids; Frank I. Tarazi; Ross J. Baldessarini


Publisher
Springer
Year
2002
Tongue
English
Weight
113 KB
Volume
161
Category
Article
ISSN
0033-3158

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The intrastriatal injection of 6-hydroxydopamine (6-OHDA) in newborn rats produces a marked striatal dopamine (DA) depletion, accompanied by a serotonin (5-HT) hyperinnervation and an up-regulation of 5-HT receptors. The aim of the present study was to investigate whether the increase in 5-HT 2 rece