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Differential effect of MK 801 and scopolamine on c-fos expression induced by L-dopa in the striatum of 6-hydroxydopamine lesioned rats

✍ Scribed by Micaela Morelli; Annalisa Pinna; Sandro Fenu; Anna Carta; Alberto Cozzolino; Gaetano Di Chiara

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
696 KB
Volume
18
Category
Article
ISSN
0887-4476

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✦ Synopsis

In rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, striatal D,-receptor-stimulated c-fos expression and turning behavior are positively modulated by D, receptor stimulation and by blockade of N-methyl-D-aspartate (NMDA) or muscarinic receptors. Combined D1/D, receptor stimulation by L-dopa activates c-fos in a manner not additive with muscarinic receptor blockade by scopolamine. On the other hand, blockade of NMDA receptors by MK 801 reduced c-fos expression induced by L-dopa while, depending on the dose of L-dopa, differentially affecting contralateral turning behavior. The results are interpreted to suggest that D, receptor stimulation amplifies D,-receptor-mediated c-fos expression by two mechanisms differentially related to muscarinic and NMDA receptors. o 1994 Wiley-Liss, Inc.

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