Stereoselective Difluoromethylenation Using Me3SiCF2SPh: Synthesis of Chiral 2,4-Disubstituted 3,3-Difluoropyrrolidines
โ Scribed by Ya Li; Jinbo Hu
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 123 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
Stereoselective Synthesis of a 2,3-Disubstituted 5-Pyrrolidinone Derivative of Quinazolin-4(3H)-one. -Thermal acylation of the quinazolinone (III) with ethyl acetoacetate and subsequent thermal cyclization of the intermediate acetoacetamide results in selective formation of the title compound (V),
Stereoselective Synthesis of 1,3-Disubstituted Hexahydro-1,4diazepin-2-ones. -A fast and facile asymmetric synthesis of the title compounds (VI), a kind of constrained peptides, involving the diastereoselective alkylation of optically pure hydroxylactam (IV) as the key step is described.