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Stereoselective Conjugate Addition of Alkyl Groups to (S)-4-(tert-Butyldimethylsilyloxy)-2-cyclopentenone Derivatives

✍ Scribed by Takayuki Yakura; Kenji Tanaka; Tomoko Kitano; Jun'ichi Uenishi; Masazumi Ikeda


Book ID
108370956
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
127 KB
Volume
56
Category
Article
ISSN
0040-4020

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The Michael addition of lithium or magnesium organocuprates and sodium dimethyl malonate to 2-alkylated 3,4-didehydropymglutamates 7, prepared from the corresponding 4-substituted sulfoxides pyroglutamates or from benzophenone imine of glycine ethyl ester or nittile, takes place in a stereoselective