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Stereoselective binding of tertatolol and of 4-hydroxytertatolol to human plasma proteins

✍ Scribed by G. Bastian; S. Urien; F. Brée; P. Jolliet; I. Rocher; O. Crambes; J. P. Tillement

Book ID
113006761
Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
412 KB
Volume
17
Category
Article
ISSN
0378-7966

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Stereoselective binding of zopiclone to
Stereoselective binding of zopiclone to human plasma proteins
✍ Christine Fernandez; François Gimenez; Alain Thuillier; Robert Farinotti 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 63 KB 👁 2 views

The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and ␣1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 ± 5.5%, 83.8 ± 5.2%, and 75