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Stereoselective binding of disopyramide to human plasma protein

✍ Scribed by John J. Lima; Gail L. Jungbluth; Thomas Devine; Larry W. Robertson


Book ID
118340529
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
266 KB
Volume
35
Category
Article
ISSN
0024-3205

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The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and ␣1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 ± 5.5%, 83.8 ± 5.2%, and 75

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