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Stereoselective Binding of Disopyramide to Plasma Proteins

✍ Scribed by Luisa Valdivieso; Kathleen M. Giacomini; Wendel L. Nelson; Robert Pershe; Terrence F. Blaschke


Book ID
114421181
Publisher
Springer US
Year
1988
Tongue
English
Weight
416 KB
Volume
05
Category
Article
ISSN
0724-8741

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The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and ␣1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 ± 5.5%, 83.8 ± 5.2%, and 75

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