Stereodivergent synthesis of 1,3-polyols
β Scribed by Yuji Mori; Makoto Suzuki
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 99 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A new general method for the iterative asymmetric synthesis of anti-l,3-polyol chains has been developed. The 0t,eg-bisalkylation of 2,2-dimethyl-l,3-dioxan-5-one SAMP-hydrazone 1 with benzyloxymethylchloride as the second electrophile leads to virtually diastereo-and enantiopure substituted 2,2-dim
## Abstract Depending on the choice of solvent either synβ or antiβdiastereomers can be obtained as protected 1,3βdiamine structures.
## Abstract A stereoselective formal synthesis of diastereoisomers of 1,3βpolyol/__Ξ±__βpyrone antifungal natural products isolated from __Ravensara anisata__ has been achieved involving epoxide opening and asymmetric allylation as key steps.