Stereocontrolled convergent synthesis of 1,3-polyol
β Scribed by Tadashi Nakata; Toshiro Suenaga; Takeshi Oishi
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 235 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
A method for the stereoselective synthesis of syn-1,3polyols using a chiral building block 1 is described. High wstereoselectivity in the reduction of 8-hydroxy ketones was achieved using lithium aluminum hydride-lithium iodide.
We have described a convergent asymmetric synthesis of the polyol fragment of amphotericin B that utilizes a versatile dienolate aldol addition reaction of furfural to rapidly assemble the constituent polyol subunit. This strategy allows for the efficient synthesis of large quantities of the desired