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Convergent synthesis of a polyol chain with 4-acetoxy-1,3-dioxanes using a 1,1-bis((trimethylsilyl)methyl)ethene linchpin

โœ Scribed by Scott D. Rychnovsky; Olga Fryszman; Uday R. Khire


Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
230 KB
Volume
40
Category
Article
ISSN
0040-4039

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Asymmetric synthesis of a branched-chain
โœ Anna Budziล„ska; Wojciech Sas ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 86 KB

## Methyl 4-(5-nitro-1,3-dioxaspiro[5.5] undecan-5-yl)but-2-enoate 2, obtained from the palladium(0)-catalyzed reaction of a salt of 5-nitro-1,3-dioxane 1 with methyl g-bromocrotonate, was converted into the title piperidinone (ee 78%) in three steps.