Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines
✍ Scribed by Dr. Gang Lu; Tatsuhiko Yoshino; Dr. Hiroyuki Morimoto; Dr. Shigeki Matsunaga; Prof. Dr. Masakatsu Shibasaki
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 357 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0044-8249
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## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard Brønsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)
## Abstract **Weich hilft hart**: Die Titelreaktion zwischen Thioamiden und __N__‐(Diphenylphosphinoyl)iminen nutzt die kooperative Katalyse einer weichen Lewis‐Säure und einer harten Brønsted‐Base, um Thioamid‐Kohlenstoff‐Pränucleophile in Mannich‐Produkte zu überführen (siehe Schema). Folgereakti