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Stereocontrolled Total Synthesis of Amphidinolide X via a Silicon-Tethered Metathesis Reaction

✍ Scribed by Rodríguez-Escrich, Carles; Urpí, Fèlix; Vilarrasa, Jaume


Book ID
127166824
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
591 KB
Volume
10
Category
Article
ISSN
1523-7060

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Total synthesis of octalactin A via ring
✍ Keith R Buszek; Nagaaki Sato; Youngmee Jeong 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 93 KB

A new total synthesis of the novel lactone natural product octalactin A is described. The key step involves the facile construction of the eight-membered lactone core via ring-closing metathesis (RCM). This oxocene was elaborated to give the powerful antitumor agent octalactin A.