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Stereocontrolled synthesis of a C(1)-C(15) segment for the marine macrolides swinholide A and scytophycin C: use of a vinylogous Mukaiyama aldol reaction

โœ Scribed by Paterson, Ian; Smith, Julian D.


Book ID
126318108
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
490 KB
Volume
57
Category
Article
ISSN
0022-3263

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Studies in marine macrolide synthesis: S
โœ Ian Paterson; Cameron J Cowden; Michael D Woodrow ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

The aplyronine C I-CII subunit 4, containing 4 stereocentres and the (E,E)-diene system, was prepared in 7 steps from ethyl ketone (R)-8 using a boron-mediated anti aldol reaction. The corresponding C 15-C27 subunit 5, containing 6 stereogenic centres and an (E)-alkene, was obtained in 10 steps from