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A stereocontrolled synthesis of a C19-C32 / C17-C30 Segment for swinholide A and misakinolide A, Cytotoxic dimeric macrolides from theonella swinhoei.

โœ Scribed by Ian Paterson; John G. Cumming


Book ID
108380322
Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
293 KB
Volume
33
Category
Article
ISSN
0040-4039

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Structural units corresponding to the Clc-C2a and C32-C3B segments of amphotericin B were synthesized from a single chiral progenitor. In the previous paper,' we described an efficient and convergent synthesis of the Cl-Cl3 segment of amphotericin B2 starting with (S)-4-hydroxymethyl butyrolactone w