Stereochemistry of the baker's yeast-mediated reductive conversion of furfurol into 2-furylmethanethiol
β Scribed by Giovanni Fogliato; Giovanni Fronza; Claudio Fuganti; Piero Grasselli; Stefano Servi; Gioia Zucchi
- Publisher
- Springer Netherlands
- Year
- 1995
- Tongue
- English
- Weight
- 129 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0141-5492
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π SIMILAR VOLUMES
Enantioselective reduction of 2-allyl-2-carboethoxy-cyclopentanone (2) was accomplished in high enantiomeric excess (> 99%), using baker's yeast in the presence of CuO, to obtain the (+)-2-allyl-2carboethoxycyclopentanol derivative (6). This methodology also provides an entry to corresponding p-keto
The nsults from the baker's yeast-mediated reduction of the acetates 3a-d and the methyl ethers 5a-d wete compared with the same biotransformation which converts the a-hydroxy ketones lad into the (R)-diols 2ad (90-989bee); the acetates 3ad afford the (S)-monoacetates 4o-d (7294% ee) and the methyl