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Baker's yeast-mediated reduction of α-hydroxy ketones and derivatives: The steric course of the biotransformation

✍ Scribed by Patrizia Ferraboschi; Paride Grisenti; Ada Manzocchi; Enzo Santaniello

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
745 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

The nsults from the baker's yeast-mediated reduction of the acetates 3a-d and the methyl ethers 5a-d wete compared with the same biotransformation which converts the a-hydroxy ketones lad into the (R)-diols 2ad (90-989bee); the acetates 3ad afford the (S)-monoacetates 4o-d (7294% ee) and the methyl ethers Sad arc reduced to the (R)-moncethers 6sd (64-76% ee).

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✍ Ryuuichirou Hayakawa; Kazumi Nozawa; Kimihiko Kimura; Makoto Shimizu 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 613 KB

Improvement of the enantioselectivity and enhancement of the reactivity were achieved in the bakers' yeast reduction of the (x-and 15-keto ester derivatives by the Addition of a sulfur compound. High enanfioselectivity in the bakers' yeast reduction of keto esters was accomplished by using combinati