Hantxsch cyclization of cyanoethyl3-aminwrotonate and (E,Z)-4dialkoxymethyl-2-benzylidene-acetoacetates (5a,b) afforded-3,4-rrons-2-hydroxy-l.2,3,4-tcuahydropyridine (Ya,b) in high stereoselectivity. In the last decade, synthetic studies of 1,4dihydropyridine derivatives have been carried out in many research institutes all over the world because of their attractive biological activities as calcium antagonists.1 The Hantzsch-type condensation reaction2 has been widely used to prepare 1,4dihydropyridines, the most popular of which are the 2,6-dimethyl derivatives such as nifedipine (1)3. By employing the Hantzsch method, 1.4dihydropyridines were obtained directly without formation of the reaction intermediates 2-hydroxy-1,2,3,4tetrahydropyridines. Contrary to the ordinary reaction, the Hantzsch reaction using ethyl 4-trifluoromethyl acetoacetate instead of methylacetoacetate yielded 2-hydroxy-1,2,3,4-tetrahyropyridines (2a,b).4 However. the stereochemistry remains unclear. In this paper, we report a Hantzsch-type reaction of using rldimethoxylmethyl acetoacetate which gives 3,4-rruns-2-hydroxy-1,2,3,4_tetrahydropyridine (7a,b) predominance with high stereoselectivity.