Stereochemistry of hydroboration of 3(or 5)-methyl-4-phenyl-1,2,5,6-tetrahydropyridines
✍ Scribed by M.A. Iorio; G. Nuñez Barrios; E. Menichini; A. Mazzeo-Farina
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 385 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa
The title compound, C 29 H 24 Br 2 , has crystallographic twofold rotation symmetry. The Br atom in the 2 position is disordered with the methyl group in the 6 position. The biphenyl bridge bond distance and the torsion angle between the rings are in good agreement with similar previously reported s
## Abstract A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2‐Pyridin‐3‐ylbenzimidazoles **3a‐d** have been synthesized by condensation of 3‐pyridinecarbox‐aldehyde **1** with substituted 1,2‐phenylenediamines **2a‐d** following oxidat