Asymmetric hydroboration of 1-methyl-1,2,3,6-tetrahydropyridine
✍ Scribed by Robert E. Lyle; Courtland K. Spicer
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- French
- Weight
- 168 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A useful approach for the synthesis of pharmacologically active tetrahydropyridinylbenzimidazoles is described. 2‐Pyridin‐3‐ylbenzimidazoles **3a‐d** have been synthesized by condensation of 3‐pyridinecarbox‐aldehyde **1** with substituted 1,2‐phenylenediamines **2a‐d** following oxidat
## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP