✦ LIBER ✦
Ca++-modulators. Unusual highly stereospecific hantzsch-like cyclization: first authenticated example of 2-chloromethylene-1,2,3,4-tetrahydropyridine
✍ Scribed by M. Frigerio; A. Zaliani; C. Riva; G. Palmisano; T. Pilati; C.A. Gandolfi
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 260 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Hantzsch cyclization of ethyl 4chloro-2-benzylidene-acetoacetates 5 with methyl 3-aminocrotonate 6 leads to 2chloromethylene-l,2,3,4-tetrahydropyridine-3,5-dicarboxylic esters 2. X-ray structure analysis and 'H-NMR of 7a established the configuration at Cs-C, as m, with borh the two bulky