Yeast reduction of methyl 3-oxnpcntanoate gives the L-hydroxy ester when bakers' yeast is immobilized by magnesium alginate and the reaction is run under a high concentration of magnesium ion. The D-hydroxy ester is obtained under normal reaction conditions. Asymmetric reduction of ketones by yeast
✦ LIBER ✦
Stereochemical control of microbial reduction. 2. Reduction of β-keto esters by immobilized bakers' yeast
✍ Scribed by Kaoru Nakamura; Masato Higaki; Kazutoshi Ushio; Shinzaburo Oka; Atsuyoshi Ohno
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 255 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically acti