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Staurosporine and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury

✍ Scribed by Yadong Goodman; Mark P. Mattson


Book ID
115804749
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
381 KB
Volume
650
Category
Article
ISSN
0006-8993

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## Abstract Amyloid‐β peptide (Aβ) has been implicated in the etiopathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms underlying Aβ neurotoxicity remain to be elucidated. This study showed that Aβ treatment resulted in the increased phosphorylation (activation) of MLK3, MKK7