Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

17β-Estradiol attenuates oxidative impai

17β-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid β-peptide and iron

✍ Jeffrey N. Keller; Ariane Germeyer; James G. Begley; Mark P. Mattson 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

Synapse loss, deposits of amyloid ␤-peptide (A␤), impaired energy metabolism, and cognitive deficits are defining features of Alzheimer's disease (AD). Estrogen replacement therapy reduces the risk of developing AD in postmenopausal women. Because synapses are likely sites for initiation of neurodeg