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K+ channel openers protect hippocampal neurons against oxidative injury and amyloid β-peptide toxicity

✍ Scribed by Yadong Goodman; Mark P. Mattson


Book ID
113128105
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
578 KB
Volume
706
Category
Article
ISSN
0006-8993

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## Abstract Amyloid‐β peptide (Aβ) has been implicated in the etiopathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms underlying Aβ neurotoxicity remain to be elucidated. This study showed that Aβ treatment resulted in the increased phosphorylation (activation) of MLK3, MKK7