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Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

โœ Scribed by Wakao Sato; Keisuke Yusa; Mikihiko Naito; Takashi Tsuruo


Book ID
117055180
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
362 KB
Volume
173
Category
Article
ISSN
0006-291X

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Induction of apoptosis in prostatic tumo
โœ Zhang, Haichao; Hoang, Thuc; Saeed, Badr; Ng, Shi-Chung ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 721 KB

We are interested in studying the possibility of modulating prostatic cell growth by manipulating apoptosis. Here we show that 1 pM staurosporine (STS) induces a human androgen-independent prostatic tumor cell line, DU145, to undergo dramatic changes in morphology and results in programmed cell deat