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A protein kinase Cβ inhibitor attenuates multidrug resistance of neuroblastoma cells

✍ Scribed by Karin Svensson; Christer Larsson

Book ID
115010504
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
357 KB
Volume
3
Category
Article
ISSN
1471-2407

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Multidrug resistance (MDR) is frequently associated with overexpression of a 170-kDa P-glycoprotein (Pgp). Data suggest altered protein kinase C (PKC) activity in cells expressing the multidrug-resistant phenotype. The staurosporine derivative CGP 4 I25 I, an experimental anticancer drug, has been s