Reduced drug accumulation and multidrug
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Jong Seok Lee; Stefania Scala; Yoshihito Matsumoto; Bruce Dickstein; Rob Robey;
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Article
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1997
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John Wiley and Sons
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English
โ 201 KB
MCF-7 human breast cancer cells selected in Adriamycin in the presence of verapamil developed a multidrug resistant phenotype, which was characterized by as much as 100,000-fold resistance to mitoxantrone, 667-fold resistance to daunorubicin, and 600-fold resistance to doxorubicin. Immunoblot and PC