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Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells

✍ Scribed by Yan-Ping Hu; Bushra Haq; Kermit L Carraway; Niramol Savaraj; Theodore J Lampidis

Book ID: 113993458
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 187 KB
Volume: 65
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(03)00086-8

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## Abstract P‐glycoprotein (P‐gp) is a plasma membrane glycoprotein that has been signaled as a primary cause of multidrug resistance (MDR) in tumors. We performed a yeast 2‐hybrid screen using the C‐terminal domain of P‐gp and identified 2 small GTPases involved in vesicular trafficking, Rab4 and