In 1948, the first randomized controlled trial was published by the English Medical Research Council in the "British Medical Journal". Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to little sensit
Statistics Applied to Clinical Trials
โ Scribed by Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas (auth.)
- Publisher
- Springer Netherlands
- Year
- 2000
- Tongue
- English
- Leaves
- 105
- Category
- Library
No coin nor oath required. For personal study only.
โฆ Table of Contents
Front Matter....Pages i-xi
Hypotheses, Data, Stratification....Pages 1-12
The Analysis of Efficacy Data of Drug Trials....Pages 13-28
The Analysis of Safety Data of Drug Trials....Pages 29-34
Equivalence Testing....Pages 35-37
Statistical Power and Sample Size....Pages 38-44
Interim Analyses....Pages 45-50
Multiple Statistical Inferences....Pages 51-58
Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism....Pages 59-67
Meta-Analysis....Pages 68-79
Capitum Selectum, Crossover Studies with Continuous Variables: Power Analysis....Pages 80-87
Capitum Selectum: Post-Hoc Analysis in Clinical Trials, a Case for Logistic Regression Analysis....Pages 88-91
Back Matter....Pages 93-97
โฆ Subjects
Statistics for Life Sciences, Medicine, Health Sciences
๐ SIMILAR VOLUMES
<P>The previous three editions of this book, rather than having been comprehensive, concentrated on the most relevant aspects of statistical analysis. Although well-received by students, clinicians, and researchers, these editions did not answer all of their questions. This updated and extended edit
Approaching the topic from an explanatory rather than mathematical stance, Cleophas and Zwinderman (both affiliated with the European Interuniversity College of Pharmaceutical Medicine Lyon, France) present a textbook designed for use in pharmaceutical education. They cover the use of statistical an
<P>The previous three editions of this book, rather than having been comprehensive, concentrated on the most relevant aspects of statistical analysis. Although well-received by students, clinicians, and researchers, these editions did not answer all of their questions. This updated and extended edit
<p><P>From the reviews of the fourth edition:</P><P>"Readership: Students, physicians and investigators interested in statistical methods for clinical trials. This book was originally written for a course in medical statistics given in the EU sponsored program European Interuniversity Diploma of Pha