A simple statistical extension of the Flory theory of excluded volume is developed, and applied to random heteropolymer collapse and a simple model of protein folding. Sequence heterogeneity is found to lead to new effects. The nucleation of protein folding is also briefly considered.
Statistical mechanics of heteropolymer folding
β Scribed by Giulia Iori; Enzo Marinari; Giorgio Parisi; M. Vittoria Struglia
- Book ID
- 103894613
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 240 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0378-4371
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It is hard to construct theories for the folding of globular proteins because they are large and complicated molecules having enormous numbers of nonnative conformations and having native states that are complicated to describe. Statistical mechanical theories of protein folding are constructed arou