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Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin

✍ Scribed by Zeljko M. Prijovich; Yu-Lin Leu; Steve R. Roffler

Book ID: 113993677
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 159 KB
Volume: 66
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(03)00472-6

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## Abstract Kinetic and thermodynamic analysis of the 9‐nitrocamptothecin (9NC) hydrolysis reaction in the presence and absence of human serum albumin (HSA) in phosphate‐buffered saline (PBS) of pH 7.4 was carried out by first derivative absorption spectroscopy. The thermodynamic parameters determi