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Kinetic and thermodynamic studies of 9-aminocamptothecin hydrolysis at physiological pH in the presence of human serum albumin

✍ Scribed by Patel, Deval; Rahman, Shahidur; Savva, Michalakis


Book ID
122363637
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
957 KB
Volume
49
Category
Article
ISSN
0928-0987

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## Abstract Kinetic and thermodynamic analysis of the 9‐nitrocamptothecin (9NC) hydrolysis reaction in the presence and absence of human serum albumin (HSA) in phosphate‐buffered saline (PBS) of pH 7.4 was carried out by first derivative absorption spectroscopy. The thermodynamic parameters determi

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## Abstract To accurately derive the kinetic and thermodynamic parameters governing the hydrolysis of the lactone ring at physiological pH, a derivative spectrophotometric technique was used for the simultaneous estimation of lactone and carboxylate forms of camptothecin (CPT). The hydrolysis of th