The role of pH and serum albumin in the metabolic conversion of 9-nitrocamptothecin to 9-aminocamptothecin by human hematopoietic and other cells
β Scribed by P. Pantazis; N. Harris; J. Mendoza; B. Giovanella
- Book ID
- 114791939
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 225 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0902-4441
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## Abstract Kinetic and thermodynamic analysis of the 9βnitrocamptothecin (9NC) hydrolysis reaction in the presence and absence of human serum albumin (HSA) in phosphateβbuffered saline (PBS) of pH 7.4 was carried out by first derivative absorption spectroscopy. The thermodynamic parameters determi
Albumin is a major carrier of drugs and fatty acids in biological fluids. These protein-drug complexes serve to solubilize, transport these compounds to sites of action, and have been associated with increased half-life for these compounds. The authors are interested in the pH and temperature effect