✦ LIBER ✦

Stability of cytogenetic alterations in a human melanoma cell line and five clonal derivatives

✍ Scribed by Edmundo Jose de Lucca; Sen Pathak; Mei-Chi Peng Cheung

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 763 KB
Volume: 41
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910410222

No coin nor oath required. For personal study only.

✦ Synopsis

A cytogenetic study was done on a human malignant melanoma cell line and its 5 clones. Chromosome banding analysis indicated the presence of 7 "shared" markers (M) and 9 unique markers (m) that were present only in the clones. Chromosomes I, 5, 9, 12, 17 and 21 were involved in M-markers and chromosomes I, 2.4.6.8.9, I I, 16, 17, 18 and 21 were involved in m-marker formation. Both parental and clonal lines had near-triploid chromosome numbers. A number of M-markers were isochromosomes of the short (p) and long (4) arms of chromosome I. Our cytogenetic data indicate that the parental line contained rubpopulations of cells that were in different stages of karyotypic evolution.

📜 SIMILAR VOLUMES

Distinct patterns of DNA copy number alt

Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma-derived cell lines

✍ J. Greshock; K. Nathanson; A. Medina; M. R. Ward; M. Herlyn; B. L. Weber; T. Z. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 1 views

## Abstract A majority of malignant melanomas harbor an oncogenic mutation in either __BRAF__ or __NRAS__. If __BRAF__ and __NRAS__ transform melanoma cells by a similar mechanism, then additional genetic aberrations would be similar (or random). Alternatively, distinct mutation‐associated changes

Metastasis of a human melanoma cell line

Metastasis of a human melanoma cell line in the nude mouse

✍ E. Lynette Wilson; Maria F. R. M. Gartner; J. A. H. Campbell; Eugene B. Dowdle 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 457 KB

A human melanoma cell line has been established which when inoculated subcutaneously into nude mice, is consis-tent1 y metastatic. In order to document blood-borne spread. apparent. Macroscopically detectable metastatic spread at autopsy was reliably indicated by weight loss of the animals. Metastas

Clonal derivatives of a herpes type 2 tr

Clonal derivatives of a herpes type 2 transformed hamster cell line (333-8-9): Cytogenetic analysis, tumorigenicity and virus sequence detection

✍ Christine D. Copple; James K. McDougall 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 917 KB

## Abstract The characteristics of the Syrian hamster cell line (333‐8‐9), putatively transformed by herpes virus type 2 (HSV‐2), strain 333, have been examined. The line has been cloned and the clones characterized cytogenetically and morphologically. The original line and the clones have been ass

Detection of tumor-associated antigen in

Detection of tumor-associated antigen in human melanoma cell line supernatants

✍ Elizabeth A. Grimm; Hulbert K. B. Silver; Jack A. Roth; Darwin O. Chee; Rishab K 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 477 KB

## Abstract Spent tissue culture medium (CDM‐S) removed from a single cell line of human malignant melanoma grown in serum‐free CDM, contained tumor‐associated antigenic activity. Antibodies to CDM‐S measured by complement fixation were detected in 44% (31/70) melanoma, 55% (15/27) sarcoma, 63% (24

Subcellular localization, redistribution

Subcellular localization, redistribution and photobleaching of sulfonated aluminum phthalocyanines in a human melanoma cell line

✍ Q. Peng; G. W. Farrants; K. Madslien; J. C. Bommer; J. Moan; H. E. Danielsen; J. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 887 KB

lntracellular localization, intracellular translocation and photobleaching following non-lethal laser microirradiation of the fluorescing derivatives of sulfonated aluminum phthalocyanines (AI-PcS,, n = 1-4) in a human melanoma cell line (LOX) were studied by means of confocal laser scanning microxo

Receptor-mediated cyotoxicity of a-MSH f

Receptor-mediated cyotoxicity of a-MSH fragments containing melphalan in a human melanoma cell line

✍ R. Morandini; H. Suli-Vargha; A. Libert; B. Loir; J. Botyánszki; K. Medzihradszk 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 553 KB

Four a-MSH drug conjugates have been synthesized, 2 Cterminal (Pep 3 and 4) and 2 central fragments (Pep I and 2), the latter being the 4-10 sequence known to be the main a-MSH-receptor-recognition site. Melphalan was introduced into each sequence at different locatiom. Their ability to recognize a-