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Stability-indicating sulfa drug analysis using high-performance liquid chromatography

✍ Scribed by H. Umagat; P. F. McGarry; R. J. Tscherne

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
288 KB
Volume
68
Category
Article
ISSN
0022-3549

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✦ Synopsis

Sensitive and efficient methods for sulfonamide determination as single entities and in combination with other drug substances in pharmaceutical dosage formulations were developed using high-performance liquid chromatography. These stability-indicating procedures involved a nitrile bonded phase column and nonaqueous mobile phases having diverse polarities. Sample potency was determined using peak height measurements. The methods may be used to determine trace sulfonamide quantities because detection limits are in the nanogram range.

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