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Stability-indicating assay for chlorthalidone formulation: Evaluation of the USP analysis and a high-performance liquid chromatographic analysis

✍ Scribed by John Bauer; John Quick; Suzanne Krogh; Douglas Shada

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
381 KB
Volume
72
Category
Article
ISSN
0022-3549

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✦ Synopsis

An investigation of the USP assay of chlorthalidone tablets showed that variable degradation of chlorthalidone occurred during assay preparation. The degradation products were isolated and identified. A stability-indicating high-performance liquid chromatographic (HPLC) assay which separates the degradation products from chlorthalidone was developed and used to examine the present USP preparation. The HPLC assay is suggested as an alternate.

Keyphrases Chlorthalidone-high-performance liquid chromatography, stability-indicating assay, comparison with the USP analysis 0 Degradation products-of chlorthalidone, high-performance liquid chromatographic determination, comparison with the USP analysis 0 USP analysis-for chlorthalidone and degradation products, comparison to a high-performance liquid chromatographic assay Chlorthalidone (I) is a monosulfamyl diuretic used in the treatment of hypertension. The official analysis of chlorthalidone tablets, as prescribed in the United States Pharmacopeia, is a spectrophotometric assay (1). Chlorthalidone has been quantitated in various media using a variety of methodologies (2-8). The major techniques in

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