Stability-indicating assay of acetaminophen in an effervescent tablet by ion-pair high-performance liquid chromatography

✍ Scribed by F. J. Sena; J. T. Piechocki; K. L. Li

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 192 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600681138

✦ Synopsis

A stability-indicating analytical method is described for determining acetaminophen and its degradation product, p-aminophenol, in an affervescent tablet. Tablets assayed by ion-pair high-performance reversed-phase liquid partition chromatography required no sample cleanup. The method applied to tablets containing 325 mg of acetaminophen yielded an average recovery of 99.6% with a relative standard deviation of 0.70% (n = 10). As little as 0.005% p-aminophenol could be detected.