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Src activation regulates anoikis in human colon tumor cell lines

✍ Scribed by Windham, T Christopher; Parikh, Nila U; Siwak, Doris R; Summy, Justin M; McConkey, David J; Kraker, Alan J; Gallick, Gary E

Book ID
110067125
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
252 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Detachment of anchorage‐dependent normal epithelial cells from their substratum causes the type of apoptosis known as anoikis, whereas malignant cells can proliferate independently of anchorage. Because __src__ and __ras__ oncogenes are activated in many human cancers, we investigated t