Activities of purine-metabolizing enzymes in human colon carcinoma cell lines and xenograft tumors
β Scribed by Gerald W. Crabtree; Daniel L. Dexter; Johanna D. Stoeckler; Todd M. Savarese; Lucy Y. Ghoda; Timothy L. Rogler-Brown; Paul Calabresi; Robert E. Parks Jr.
- Book ID
- 115775601
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 896 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0006-2952
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The activities of 5 enzymes involved in the pyrimidine metabolism were measured in xenografts of 8 human colon adenocarcinomas and in the corresponding primary tumors and normal tissues. The enzymes studied were thymidine kinase, thymidine phosphorylase, uridine kinase, uridine phosphorylase and thy
Different cell lines, 2 from human colon carcinoma (LoVo and HT29) and I from Chinese hamster ovary (CHO K-I), were examined to assess the effect of deoxycoformycin (dCF), an inhibitor of adenosine deaminase (ADA), and 2'-deoxyadenosine (dAdo) on their growth. When used alone, neither dCF or dAdo we