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Squalene biosynthesis. Role of the 3-methyl group in farnesyl pyrophosphate

โœ Scribed by Ortiz de Montellano, Paul R.; Castillo, Rafael; Vinson, Wayne; Wei, Jeng Shu


Book ID
126290110
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
295 KB
Volume
98
Category
Article
ISSN
0002-7863

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A simple synthetic route to a proposed i
โœ E.J. Corey; Paul R. Ortiz de Montellano ๐Ÿ“‚ Article ๐Ÿ“… 1968 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 154 KB

Recently a new intermediate in the biosynthesis of squalene has been obtained from farnesyl pyrophosphate as substrate in a yeast homogenate containing minimal amounts of reduced nicotinamide adenine di-'nucleotide (NADP-H) (1). On the basis of a number of experimental results, structure I was sugge