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Stereochemistry of the hydrogen transfer to squalene during its biosynthesis from farnesyl pyrophosphate

โœ Scribed by Bengt Samuelsson; DeWitt S. Goodman

Book ID
118848147
Publisher
Elsevier Science
Year
1963
Tongue
English
Weight
227 KB
Volume
11
Category
Article
ISSN
0006-291X

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A simple synthetic route to a proposed i
A simple synthetic route to a proposed intermediate in the biosynthesis of squalene from farnesyl pyrophosphate
โœ E.J. Corey; Paul R. Ortiz de Montellano ๐Ÿ“‚ Article ๐Ÿ“… 1968 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 154 KB

Recently a new intermediate in the biosynthesis of squalene has been obtained from farnesyl pyrophosphate as substrate in a yeast homogenate containing minimal amounts of reduced nicotinamide adenine di-'nucleotide (NADP-H) (1). On the basis of a number of experimental results, structure I was sugge