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A simple synthetic route to a proposed intermediate in the biosynthesis of squalene from farnesyl pyrophosphate

โœ Scribed by E.J. Corey; Paul R. Ortiz de Montellano

Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
154 KB
Volume
9
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Recently a new intermediate in the biosynthesis of squalene has been obtained from farnesyl pyrophosphate as substrate in a yeast homogenate containing minimal amounts of reduced nicotinamide adenine di-'nucleotide (NADP-H) (1). On the basis of a number of experimental results, structure I was suggested for the new substance which was designated as "Compound Xx' and which was shown to be a Cgo-pyrophosphate convertible to squalene (II) in the presence of NADP-H either by yeast homogenate or rat liver microsomes

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