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Spirocyclic systems derived from pyroglutamic acid

โœ Scribed by Cowley, Andrew R.; Hill, Thomas J.; Kocis, Petr; Moloney, Mark G.; Stevenson, Robert D.; Thompson, Amber L.


Book ID
118201903
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
431 KB
Volume
9
Category
Article
ISSN
1477-0520

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The ot, l~-unsaturated bicyclic lactams 3a,e, prepared from (S)-pyroglutamic acid. are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3e has very superior reactivity with several dienes and dipoles under mild reaction conditions.