Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions
β Scribed by Jonathan H. Bailey; David T. Cherry; Katherine M. Crapnell; Mark G. Moloney; Sung Bo Shim; Mark J. Bamford; R.Brian Lamont
- Book ID
- 104207991
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 779 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
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β¦ Synopsis
The ot, l~-unsaturated bicyclic lactams 3a,e, prepared from (S)-pyroglutamic acid. are useful substrates for cycloaddition reactions, giving excellent regio-and diastereocontrol; however, lactam 3e has very superior reactivity with several dienes and dipoles under mild reaction conditions.
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