Spiro piperidines. I. Synthesis of spiro[isobenzofuran-1(3H), 4'-piperidines] and spiro[isobenzofuran-1(3H), 3'-piperidines]
โ Scribed by Marxer, Adrian; Rodriguez, Herman R.; McKenna, Joseph M.; Tsai, Hsin Mei
- Book ID
- 120328849
- Publisher
- American Chemical Society
- Year
- 1975
- Tongue
- English
- Weight
- 923 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The spirocyclic indoline ring system represents an important scaffold for the discovery of novel therapeutics. Herein, we describe the synthesis of 1,1 0 -H-spiro[indoline-3,3 0 -piperidine] using an intramolecular palladium-catalyzed a-arylation reaction.
## Abstract The title compounds **14โ16** were obtained __via__ an intramolecular __Mannich__ condensation by treating **11โ13** with CH~2~O at RT. The unsaturated ketones **14** and **15** were reduced to the allylic alcohols **18** and **19** respectively. Ring cleavage of compound **18** on trea